Use this url to cite publication: https://hdl.handle.net/20.500.12259/58350
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Synthesis of carbazole-based derivatives as potential efflux pump inhibitors
Type of publication
Konferencijų tezės nerecenzuojamame leidinyje / Conference theses in non-peer-reviewed publication (T2)
Title
Synthesis of carbazole-based derivatives as potential efflux pump inhibitors
Is part of
COINS 2018: 13th international conference of life sciences, 28 February – 2 March 2018: book of abstracts. Vilnius: Vilniaus universitetas, Gyvybės mokslų centras, 2018
Date Issued
Date Issued |
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2018 |
Publisher
Vilnius: Vilniaus universitetas, Gyvybės mokslų centras, 2018
Extent
p. 81-82
Field of Science
Abstract
Antimicrobial resistance is a worldwide problem in human and veterinary medicine. It occurs when micro-organisms such as bacteria, fungi, viruses, and parasites evolve resistance to antimicrobial substances, like antibiotics, antifungals and others. This occurs naturally during adaptation to the environment or when microorganisms come into contact with antimicrobials. The appearance of multiple resistant bacteria of human and veterinary origin is accelerated due to the inappropriate or excessive use of antimicrobials. As a result, medicines that were once effective in people and animals become less effective or not effective at all, leading to a reduced ability to treat infections. It seems that antibiotic resistance is inevitable. Therefore many different solutions have been proposed to solve this problem. As the ability to pump antibiotics out of cells is a common feature of the microbes and their pathogenic relatives and is the most widespread form of resistance to most classes of antibiotics that is why it is very important to discover molecules inhibiting efflux pumps as well as to reveal the inhibition mechanisms. There is another possibility to investigate similar substances as competitors of antibiotics.[...]
Type of document
type::text::conference output::conference proceedings::conference paper
Language
Anglų / English (en)
Coverage Spatial
Lietuva / Lithuania (LT)