Regeneracinės medicinos technologijos
Dalyko anotacija lietuvių kalba
Kurso metu susipažįstama regeneracinės medicinos principais. Regeneracinė medicina ir audinių inžinerija-tarpdisciplininės mokslo šakos, integruojančios įvairias fundamentinio ir taikomojo mokslo kryptis. Žaizdų gijimo patofiziologija. Eksperimentiniai regeneracijos modeliai. Audinių senėjimas. Audinių inžinerijos technologijų taikymas odos regeneracijai ir kremzlės, bei kaulų defektų reparacijai (šiuo metu taikomos gydymo strategijos). Akies audinių regeneracija. Periferinių nervų regeneravimas, eksperimentinės strategijos centrinės nervų sistemos (CNS) pažaidų gydymui. Žvilgsnis į ateitį, prototipavimo technologijos, organų spausdinimas. Bioreaktoriai, reikšmė, veikimo principai, bioreaktorių tipai. Organų konstruktų vaskuliarizavimo problema. Ateities perspektyvos.
Dalyko anotacija užsienio kalba
Introduction into the principles of regenerative medicine. Regenerative medicine and tissue engineering as emerging multidisciplinary fields integrating both fundamental and applied scientific research. Pathophysiology of wound healing. Experimental models of regeneration. Current understanding of tissue ageing processes. The use of tissue engineering technologies for skin, cartilage and bone regeneration (current therapeutic strategies). Regeneration of ocular tissues. Current strategies for regeneration and reparation of peripheral nerves and central nervous system. In vitro construction of functional vascular and cardiac tissues. Prototyping technologies, organ printing. Bioreactors, operation principles, classification. Vascularization of engineered tissue constructs. Future perspectives.
Būtinas pasirengimas dalyko studijoms
Molecular Biology, Molecular Biotechnology, Cell and Tissue Culture Technology
Dalyko studijų rezultatai
Knowing and understanding the principles of regenerative medicine.
Knowing and understanding current experimental strategies for regeneration and reconstruction of different tissues and organs.
Dalyko turinys
1. Introduction into basic principles of regenerative medicine.
2. General principles of tissue organization. Extracellular matrix.
3. Inflammation. Pathophysiology of wound healing.
4. Mechanisms of tissue regeneration. What can we learn from amphibian models of regeneration?
5. Mechanisms of tissue aging. Can we prevent, or slow down aging processes ?
6. Technologies for skin regeneration.
7. Regeneration of ocular tissues.
8. Current strategies for regeneration of bones and cartilage.
9. The strategies for regeneration and reparation of peripheral nerves.
10. Regeneration of the central nervous system. New therapeutic strategies against neurodegenerative disorders.
11. Regeneration of cardiac tissue.
12. Creating artificial organs (trachea, urine bladder, etc.).
13. Introduction into spheroids, organoids and tissue decellularization technologies.
14. The problem of artificial tissue vascularization.
15. What will future of medicine look like? A futuristic outlook.
Dalyko studijos valandomis
Lectures – 45 hours, laboratory work – 15 hours, individual work – 94 hours, examinations– 6 hours. Total 160 h.
Studijų rezultatų vertinimas
Final assessment sums the assessments of written final examination (50%), assessment of laboratory work (30%), and written mid-term examination (20%).
Literatūra
1. 2014 Daniel Eberli (Ed.), Cells and Biomaterials in Regenerative Medicine InTech Open access
https://www.intechopen.com/books/cells-and-biomaterials-in-regenerative-medicine
2. 2013 Jose A. Andrades (Ed.), Regenerative Medicine and Tissue Engineering InTech Open access
https://www.intechopen.com/books/regenerative-medicine-and-tissue-engineering
3. 2012 Jamie Davies (Ed.) Tissue Regeneration - From Basic Biology to Clinical Application InTech Open access:
https://www.intechopen.com/books/tissue-regeneration-from-basic-biology-to-clinical-application
Supplementary materials
1. 2011 A. Atala, R. Lanza, J. A. Thomson, R. Nerem, Principles of Regenerative Medicine (2nd edition) Academic Press (imprint of Elsevier), London
2. 2013 Steinhoff, Gustav (Ed.) Regenerative Medicine: From Protocol to Patient (2nd edition) Springer Science + Business Media, Dordrecht
