Association between exposure to fine particulate matter and adverse pregnancy outcomes in Kaunas
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2018 | 300 | 300 |
Epidemiological studies have suggested that maternal exposure to particles during pregnancy may be associated with adverse health outcomes including low birth weight. We examined the effect of long-term exposure to PM2.5 on birth weight. The prospective cohort study included 3292 pregnant women living in Kaunas, Lithuania. The outcomes of the study were low birth weight (LBW < 2500 g) and term low birth weight (TLBW < 2500 g; ≥ 37 weeks gestation). The annual average PM2.5 concentration at the participants’ home addresses was estimated using land use regression (LUR) model. To detect potential confounding variables odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. We used a two-piece linear spline function and multivariate logistic regression analysis to evaluate the association between exposure to PM2.5 and the risk of LBW and TLBW. The results showed that the risk of LBW and TLBW increased statistically significantly with increasing exposure to PM2.5. After adjustment for confounding variables the ORs for LBW among women exposed to the third and fourth quartiles of PM2.5 exposure were 1.27 (95 % CI 0.84–1.93) and 1.69 (95 % CI 1.14–2.50), compared with PM2.5 concentrations below the median. The risk for TLBW among women exposed to the third and fourth quartiles of PM2.5 exposure were 1.78 (95 % CI 0.85–3.73) and 2.89 (95 % CI 1.50–5.60), compared with PM2.5 concentrations below the median. Study provided evidence that maternal exposure to PM2.5 may adversely affect the birth weight; a non-linear association between exposure to PM2.5 and LBW and TLBW was detected.
Conference | ||||
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2018-05-03 | 2018-05-05 | Kaunas | LT |