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Type of publication: Konferencijų tezės nerecenzuojamuose leidiniuose / Conference theses in non-peer-reviewed publications (T2)
Field of Science: Farmacija / Pharmacy (M003);Botanika / Botany (N013)
Author(s): Balčiūnaitė, Gabrielė;Baniulis, Danas;Ragažinskienė, Ona;Juodžiukynienė, Nomeda;Pangonytė, Dalia;Savickienė, Nijolė
Title: Impact of Echinacea purpurea L. (Moench) hemagglutinin LysM to mice secondary immune response
Is part of: Science and practice 2018: 9th international pharmaceutical conference, dedicated to the 100th anniversary of independent Lithuania's pharmacy, November 9, 2018, Kaunas, Lithuania : book of abstracts. Kaunas : Lietuvos sveikatos mokslų universitetas, 2018
Extent: p. 111-111
Date: 2018
Keywords: Echinacea purpurea L;Hemaglutinins;Human health
ISBN: 9789955155867
Abstract: Hemaglutinins or lectins are highly potential therapeutic agents found in plants. Although considered as toxins, low doses of lectins acts as an antibacterial [2] and antifungal [1] substances, stimulates immune system [3]. Hemagglutinins from Echinacea purpurea L. (Moench) roots haven’t been investigated and tested on animal models in vivo. Materials and methods. Lectins from E. purpurea roots were extracted and purified by affinity chromatography, followed by mass spectrometry identification. Identified lysine motif peptidoglycan binding domain (LysM) protein fractions was peritonially injected to male Balb/C mice (n=15). Immune response to 4 weekly repeated 5 μg lectin injections were measured in mice spleen by immunohistochemical CD3 staining. Results were compared with physiological solution (n=14) and E. purpurea root tincture (n=15) peritoneal injections immunomodulatory effect to male Balb/C mice. Results. Peritoneal LysM lectin injections caused statistically significant (p<0.001) increase of T lymphocyte cell count in Balb/c mice’s spleen white pulp compared to other experimental animal groups. Conclusions. LysM lectin from E. purpurea roots causes significant secondary immune response stimulation
Affiliation(s): Botanikos sodas
Lietuvos agrarinių ir miškų mokslų centro Sodininkystės ir daržininkystės institutas
Lietuvos sveikatos mokslų universitetas
Lietuvos sveikatos mokslų universitetas. Medicinos akademija
Lietuvos sveikatos mokslų universitetas. Veterinarijos akademija
Vaistinių ir prieskon. augalų kol. Sektorius
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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