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Type of publication: Straipsnis kitose duomenų bazėse / Article in other databases (S4)
Field of Science: Biologija / Biology (N010)
Author(s): Jakutavičiūtė, Milda;Ruzgys, Paulius;Tamošiūnas, Mindaugas;Maciulevičius, Martynas;Šatkauskas, Saulius
Title: Physical methods for drug and gene delivery through the cell plasma membrane
Is part of: Transport across natural and modified biological membranes and its implications in physiology and therapy / edited by Julita Kulbacka, Saulius Šatkauskas. Cham : Springer International Publishing AG, 2017
Extent: p. 73-91
Date: 2017
Series/Report no.: (Advances in Anatomy Embryology and Cell Biology, Vol. 227, 0301-5556)
Note: Online ISBN 978-3-319-56895-9. Series Online ISSN 2192-7065. This work was supported by the grants SVE-08, 2014 and MIP-034/2013 from the Research Council of Lithuania. The authors would also like to acknowledge networking support by the COST Action TD1104
Keywords: Drug delivery;Electroporation;Sonoporation;Gene delivery
ISBN: 9783319568942
Abstract: The cell membrane represents a major barrier for efficient delivery of exogenous molecules, either pharmaceuticals or genetic material, under both in vitro and in vivo conditions. The number of methods employed to attempt safe, efficient, and local drug and gene delivery has increased during the recent years. One method for membrane permeabilization, electroporation, has already been translated to clinical practice for localized anticancer drug delivery and is termed “electrochemotherapy”. Clinical trials for gene delivery using electroporation as well as drug delivery using another cell permeabilization method, sonoporation, are also underway. This review focuses on these two methods, including their fundamental principles and state-of-the-art applications. Other techniques, such as microinjection, magnetoporation, photoporation, electrospray, and hydrodynamic and ballistic gene delivery, are also discussed
Affiliation(s): Biologijos katedra
Gamtos mokslų fakultetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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