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Type of publication: Tezės kituose recenzuojamuose leidiniuose / Theses in other peer-reviewed publications (T1e)
Field of Science: Biochemija / Biochemistry (N004);Biologija / Biology (N010)
Author(s): Vaitkevičienė, Violeta;Ragelienė, Lina
Title: Assessment of concentrations of antibiotic accumulated into Escherichia coli using mathematical modeling
Is part of: Vital nature sign : 11th international scientific conference, 19-20 October, 2017, Vilnius, Lithuania : abstract book / editors Nicola Tiso, Vilma Kaškonienė. Kaunas : Vytautas Magnus University, 2017, [no. 11]
Extent: p. 69-69
Date: 2017
Keywords: Antimicrobial activity;Escherichia coli;Tetracycline
Abstract: Nowadays bacteria can be resistant to multiple antibiotics. This study is aimed to assess the antimicrobial activity of tetracycline (TC)—against Escherichia coli during mathematical modeling. Some aspects of the tetracycline mode of action, including pH, temperature, EDTA, some heavy metals and sorption on bacteria surface were investigated. The model was then used to prove the possibility of approximating tetracycline‘s bioaccumulation using only a single species of the antibiotics, specifically neutral, zwitterionic species. Uptake of antibiotics by bacteria was described and computed as adsorption of neutral species of antibiotics with their log K values 2.36 for tetracycline. In addition, the tetracycline was combined with an extracellular solution in order to assess any synergistic effect of elements existing. The created model also made it possible to assess the speciation of tetracycline in aqueous phase under various conditions. This method could prove as a potential alternative to laboratory routine
Affiliation(s): Biochemijos katedra
Gamtos mokslų fakultetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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