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Type of publication: Konferencijų tezės nerecenzuojamuose leidiniuose / Conference theses in non-peer-reviewed publications (T2)
Field of Science: Farmacija / Pharmacy (M003);Biologija / Biology (N010)
Author(s): Mickienė, Rūta;Maruška, Audrius Sigitas;Ragažinskienė, Ona
Title: Secondary metabolites from Angelica archangelica L. synergism with enilconazolum
Is part of: The 8th International Conference on Pharmaceutical Sciences and Pharmacy Practice dedicated to the 80th anniversary of the Museum of History of Lithuanian Medicine and Pharmacy : book of abstracts : December 15, 2017 Kaunas, Lithuania / organized by the Faculty of Pharmacy of Lithuanian Health Sciences University in collaboration with Lithuanian Pharmaceutical Association and LSMU FF Alumni Association. Kaunas : Lithuanian University of Health Sciences, 2017
Extent: p. 89-89
Date: 2017
Note: ISBN 978-9955-15-517-1. Research Council of Lithuania, project No. MIP-065/2015
Keywords: Plants, medicinal;Angelica archangelica L;Metabolites
ISBN: 9789955155171
Abstract: Secondary metabolites high structural diversity are important tools of plants needed against microbes (bacteria, fungi) and viruses. Disease resistance in plants depends on the activation of coordinated, multicomponent defence mechanisms. Bioactive plant- derived secondary metabolites are useful leads to synthesize new and more active antimicrobial agents as well as substances with new pharmacological effects by repeated structural modification. It is expected that structurally modified natural products will exhibit increased potency, selectivity, duration of action, bioavailability and reduced toxicity [1]. Trichophyton spp. are fungal species that known as tinea infections in various areas in humans and animals. Enilconazolum is used antifungal drug for the treatment of both superficial and deep infections caused by Trichophyton. Essential oils are one of the most promising groups of natural compounds for the development of safer antifungal agents. Many essential oils are only fungistatic and high concentrations are needed for fungicidal activity. To enhance the efficacy of essential oils, the combined use of different oils has been evaluated recently for synergistic effects. The combination of essential oils with synthetic antifungals will probably result in a more effective therapy. Antifungal agents were tested against fungal isolates using the agar diffusion method. We used the essential oil Angelica archangelica L. The results of the agar diffusion tests indicate that these essential oil is significantly potent against Trichophyton spp. MIC assay results exhibited strong inhibition of 7 mm in most of the experimental concentrations of 50% and 1% of agar diffusion test. The MIC synergism of the essential oil Angelica archangelica L. with enilconazolum were remarkably decreased and agar diffusion test exhibited inhibition of 20 – 25 mm sterile zone. [...]
Affiliation(s): Biochemijos katedra
Biologijos katedra
Gamtos mokslų fakultetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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