Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/56948
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dc.contributor.authorMaruška, Audrius-
dc.contributor.authorUgenskienė, Rasa-
dc.contributor.authorRaulinaitytė, Danguolė-
dc.contributor.authorJuozaitytė, Elona-
dc.contributor.authorKaškonienė, Vilma-
dc.contributor.authorDrevinskas, Tomas-
dc.contributor.authorStelmakienė, Ada-
dc.contributor.authorAkuneca, Ieva-
dc.contributor.authorMakaravičius, Tomas-
dc.contributor.authorTiso, Nicola-
dc.contributor.authorBartkuvienė, Violeta-
dc.contributor.authorKornyšova, Olga-
dc.contributor.authorRagažinskienė, Ona-
dc.contributor.authorRamanauskienė, Kristina-
dc.contributor.authorBriedis, Vitalis-
dc.coverage.spatialNL-
dc.date.accessioned2018-10-07T01:07:56Z-
dc.date.available2018-10-07T01:07:56Z-
dc.date.issued2017-
dc.identifier.issn18961126-
dc.identifier.otherVDU02-000020771-
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/28282602-
dc.descriptionOriginal research article ; authors (15) ; the Study was financially supported by the Research Council of Lithuania (grant no. MIP 084/2012 ONKOFITAS)-
dc.description.abstractPURPOSE: To evaluate the antiproliferative effect of the aerial part of Chamerion angustifolium (L.) Holub. (Onagraceae) extract and its fractions in vitro. This is the first study on the anti-proliferative effect of C. angustifolium on 3 distinct breast cancer cell lines. MATERIAL/METHODS: Breast cancer cell lines MCF7, MDA-MB-468 and MDA-MB-231 were exposed to different concentrations of the water extract of C. angustifolium, where DPPH radical scavenging activity was 0.018-0.443mg/ml, expressed in rutin equivalents. Cell growth was analyzed after 24, 48 and 72h of incubation. Solid-phase extraction was applied for the fractionation of C. angustifolium water extract and MDA-MB-468 cell line growth was tested using different fractions. RESULTS: The concentrations corresponding to radical scavenging activity of 0.117 and 0.266mg/ml caused MCF7 cells growth inhibition, while in the samples exposed to the highest concentration (0.355 and 0.443mg/ml) no proliferation was register, suggesting cell death. MDA-MB-468 cell analysis showed similar responses. MDA-MB-231 demonstrated cell growth inhibition following the exposure to all analyzed high extract doses (0.117-0.443mg/ml). MDA-MB-468 cells were selected to evaluate the effect of fractions. In the samples exposed to the fraction containing the highest amount (91%) of oenothein B, at the concentration of 0.117mg/ml a pronounced cell growth inhibition while at higher concentrations (0.266 and 0.443mg/ml) no cell proliferation was observed. CONCLUSIONS: The consumption of C. angustifolium herb can be advantageous, alongside with conventional breast cancer treatmenten
dc.description.sponsorshipBiochemijos katedra-
dc.description.sponsorshipGamtos mokslų fakultetas-
dc.description.sponsorshipInstrumentinės analizės APC-
dc.description.sponsorshipLietuvos sveikatos mokslų universitetas. Medicinos akademija-
dc.description.sponsorshipLietuvos sveikatos mokslų universitetas. Medicinos akademija. Onkologijos institutas-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 158-164-
dc.language.isoen-
dc.relation.ispartofAdvances in medical sciences. Amsterdam : Elsevier, 2017, vol. 62, no. 1-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyMEDLINE-
dc.relation.isreferencedbyScopus-
dc.subjectBreast neoplasmsen
dc.subjectdrug therapyen
dc.subjectBreast neoplasmsen
dc.subjectcytologyen
dc.subjectMCF7 cellsen
dc.subjectdrug effectsen
dc.subjectAntineoplastic agents, phytogenicen
dc.subjectpharmacologyen
dc.subjectOnagraceaeen
dc.subjectchemistryen
dc.subjectPlant extractsen
dc.subjectpharmacologyen
dc.subject.otherFarmacija / Pharmacy (M003)-
dc.subject.otherBiochemija / Biochemistry (N004)-
dc.subject.otherChemijos inžinerija / Chemical engineering (T005)-
dc.titleAnalysis of antiproliferative effect of Chamerion angustifolium water extract and its fractions on several breast cancer cell linesen
dc.typeStraipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)-
dc.identifier.doihttps://doi.org/10.1016/j.advms.2016.08.002-
dc.identifier.isiWOS:000403755700022-
dcterms.bibliographicCitation23-
dc.date.updated2017-11-17T14:01Z-
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crisitem.author.deptInstrumentinės analizės atviros prieigos centras-
crisitem.author.deptBiologijos katedra-
crisitem.author.deptBiochemijos katedra-
crisitem.author.deptInstrumentinės analizės atviros prieigos centras-
crisitem.author.deptBotanikos sodas-
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crisitem.author.deptBiochemijos katedra-
crisitem.author.deptInstrumentinės analizės atviros prieigos centras-
crisitem.author.deptBiochemijos katedra-
crisitem.author.deptBiochemijos katedra-
crisitem.author.deptVaistinių ir prieskoninių augalų kolekcijų sektorius-
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications
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