Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/51703
Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Biologija / Biology (N010)
Author(s): Kaselis, Andrius;Treinys, Rimantas;Vosyliūtė, Rūta;Šatkauskas, Saulius
Title: DRG axon elongation and growth cone collapse rate induced by Sema3A are differently dependent on NGF concentration
Is part of: Cellular and molecular neurobiology. New York : Springer, Vol. 34, 2014
Extent: p. 289-296
Date: 2014
Note: ISSN: 1573-6830 (electronic version)
Keywords: Semaphorinai;Sema3A;Užpakalinių ragų ganglijai;Aksonų augimas;NGF;Augimo kūgelių kolapsas;Semaphorin;Sema3A;DRG;Axon growth;NGF;Growth cone collapse
Abstract: Regeneration of embryonic and adult dorsal root ganglion (DRG) sensory axons is highly impeded when they encounter neuronal growth cone-collapsing factor semaphorin3A (Sema3A). On the other hand, increasing evidence shows that DRG axon's regeneration can be stimulated by nerve growth factor (NGF). In this study, we aimed to evaluate whether increased NGF concentrations can counterweight Sema3A-induced inhibitory responses in 15-day-old mouse embryo (E15) DRG axons. The DRG explants were grown in Neurobasal-based medium with different NGF concentrations ranging from 0 to 100 ng/mL and then treated with Sema3A at constant 10 ng/mL concentration. To evaluate interplay between NGF and Sema3A number of DRG axons, axon outgrowth distance and collapse rate were measured. We found that the increased NGF concentrations abolish Sema3A-induced inhibitory effect on axon outgrowth, while they have no effect on Sema3A-induced collapse rate
Internet: https://hdl.handle.net/20.500.12259/51703
Affiliation(s): Biologijos katedra
Gamtos mokslų fakultetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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