Use this url to cite publication: https://hdl.handle.net/20.500.12259/49129
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Metabolic syndrome, major depression, generalized anxiety disorder, and ten-year all-cause and cardiovascular mortality in middle aged and elderly patients
Type of publication
Straipsnis Web of Science ir Scopus duomenų bazėje / Article in Web of Science and Scopus database (S1)
Author(s)
Butnorienė, Jūratė | Lietuvos sveikatos mokslų universitetas. Medicinos akademija. Endokrinologijos institutas |
Bunevičius, Adomas | Lietuvos sveikatos mokslų universitetas. Neuromokslų institutas |
Nemeroff, Charles B. | University of Miami Miller School of Medicine, Miami, FL, USA |
Norkus, Antanas | Lietuvos sveikatos mokslų universitetas. Medicinos akademija. Endokrinologijos institutas |
Cicėnienė, Vilė | Higienos institutas |
Bunevičius, Robertas | Lietuvos sveikatos mokslų universitetas. Elgesio medicinos institutas |
Title
Metabolic syndrome, major depression, generalized anxiety disorder, and ten-year all-cause and cardiovascular mortality in middle aged and elderly patients
Is part of
International journal of cardiology. Amsterdam : Elsevier, 2015, vol. 190
Date Issued
Date Issued |
---|
2015 |
Publisher
Amsterdam : Elsevier
Publisher (trusted)
Is Referenced by
ScienceDirect |
Elsevier Biobase |
Extent
p. 360-366
Field of Science
Abstract
BACKGROUND: Studies investigating specifically whether metabolic syndrome (MetS) and common psychiatric disorders are independently associated with mortality are lacking. In a middle-aged general population, we investigated the association of the MetS, current major depressive episode (MDE), lifetime MDE, and generalized anxiety disorder (GAD) with ten-year all-cause and cardiovascular disease mortality. METHODS: From February 2003 until January 2004, 1115 individuals aged 45 years and older were randomly selected from a primary care practice and prospectively evaluated for: (1) MetS (The World Health Organization [WHO], National Cholesterol Education Program/Adult Treatment Panel III and International Diabetes Federation [IDF] definitions); (2) current MDE and GAD, and lifetime MDE (Mini International Neuropsychiatric Interview); and (3) conventional cardiovascular risk factors. Follow-up continued through January, 2013. RESULTS: During the 9.32 ± 0.47 years of follow-up, there were 248 deaths, of which 148 deaths were attributed to cardiovascular causes. In women, WHO-MetS and IDF-MetS were associated with greater all-cause (HR-values range from 1.77 to 1.91; p-values ≤ 0.012) and cardiovascular (HR-values range from 1.83 to 2.77; p-values ≤ 0.013) mortality independent of cardiovascular risk factors and MDE/GAD. Current GAD predicted greater cardiovascular mortality (HR-values range from 1.86 to 1.99; p-values ≤ 0.025) independently from MetS and cardiovascular risk factors. In men, the MetS and MDE/GAD were not associated with mortality. CONCLUSIONS: In middle aged women, the MetS and GAD predicted greater 10-year cardiovascular mortality independently from each other; 10-year all-cause mortality was independently predicted by the MetS. MetS and GAD should be considered important and independent mortality risk factors in women.
Type of document
type::text::journal::journal article::research article
Language
Anglų / English (en)
Coverage Spatial
Nyderlandai / Netherlands (NL)