Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/48028
Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Jeong, Clara H;Wagner, Elizabeth D;Siebert, Vincent R;Anduri, Sridevi;Richardson, Susan D;Daiber, Eric J;McKague, Bruce;Kogevinas, Manolis;Villanueva, Cristina M;Goslan, Emma H;Luo, Wentai;Isabelle, Lorne M;Pankow, James F;Gražulevičienė, Regina;Cordier, Sylvaine;Edwards, Susan C;Righi, Elena;Plewa, Michael J
Contributor(s): Nieuwenhuijsen, Mark
Title: Occurrence and toxicity of disinfection by products in European drinking waters in relation with the HIWATE epidemiology study
Is part of: Environmental science and technology. Washington : American Chemical Society, 2012, vol. 46, iss. 21
Extent: p. 2120-2128
Date: 2012
Keywords: Toxicity;Drinking water;HIWATE;Epidemiology study
Abstract: The HIWATE (Health Impacts of long-term exposure to disinfection byproducts in drinking WATEr) project was a systematic analysis that combined the epidemiology on adverse pregnancy outcomes and other health effects with long-term exposure to low levels of drinking water disinfection byproducts (DBPs) in the European Union. The present study focused on the relationship of the occurrence and concentration of DBPs with in vitro mammalian cell toxicity. Eleven drinking water samples were collected from five European countries. Each sampling location corresponded with an epidemiological study for the HIWATE program. Over 90 DBPs were identified; the range in the number of DBPs and their levels reflected the diverse collection sites, different disinfection processes, and the different characteristics of the source waters. For each sampling site, chronic mammalian cell cytotoxicity correlated highly with the numbers of DBPs identified and the levels of DBP chemical classes. Although there was a clear difference in the genotoxic responses among the drinking waters, these data did not correlate as well with the chemical analyses. Thus, the agents responsible for the genomic DNA damage observed in the HIWATE samples may be due to unresolved associations of combinations of identified DBPs, unknown emerging DBPs that were not identified, or other toxic water contaminants. This study represents the first to integrate quantitative in vitro toxicological data with analytical chemistry and human epidemiologic outcomes for drinking water DBPs
Internet: https://hdl.handle.net/20.500.12259/48028
Affiliation(s): Aplinkotyros katedra
Gamtos mokslų fakultetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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