Contribution of ATP synthase to stimulation of respiration by Ca/sup 2+/ in heart mitochondria
Author | Affiliation | |||
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Banienė, Rasa | ||||
Date |
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2006 |
A variety of experimental conditions were applied with the aim to estimate the correlation between the contribution of ATP synthase to the respiratory flux control and the calcium-induced activation of succinate oxidation in heart mitochondria isolated from rat, rabbit and quinea pig. The sensitivity of respiration in heart mitochondria to the decrease in temperature from 37°C to 28°C decreases in the order rabbit> guinea pig > rat. Ca²+ effect on succinate oxidation rate in state 3 respiration was species- and temperature-dependent and ranged from 0 (rat, 37°C) to +44% (rabbit, 28°C). For mitochondria from all experimental animals, the increase of Ca²+ in physiological range of concentration did not change state 2 respiration rate, and the stimulatory effect of Ca²+ on state 3 respiration was more pronounced at 28°C than at 37°C. The respiratory subsystem was sensitive to Ca²+ ions only in rabbit heart mitochondria. A high positive correlation between Ca²+ ability to stimulate succinate oxidation in state 3 and the control exerted by ATP synthase over the respiratory flux provides argument confirming stimulation of ATP synthase by Ca²+ ions.
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
IEE Proceedings Systems Biology | 1.037 | 4.234 | 2.804 | 5.663 | 2 | 0.21 | 2006 | Q3 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
IEE Proceedings Systems Biology | 1.037 | 4.234 | 2.804 | 5.663 | 2 | 0.21 | 2006 | Q3 |