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Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Banienė, Rasa;Naučienė, Zita;Maslauskaitė, Sandra;Baliūtytė, Giedrė;Mildažienė, Vida
Title: Contribution of ATP synthase to stimulation of respiration by Ca/sup 2+/ in heart mitochondria
Is part of: Systems biology. London : IEEE Press, 2006, vol. 153, no. 5
Extent: p. 350-353
Date: 2006
Keywords: Mitochandria, heart;physiology;Adenosine triphosphatases
Abstract: A variety of experimental conditions were applied with the aim to estimate the correlation between the contribution of ATP synthase to the respiratory flux control and the calcium-induced activation of succinate oxidation in heart mitochondria isolated from rat, rabbit and quinea pig. The sensitivity of respiration in heart mitochondria to the decrease in temperature from 37°C to 28°C decreases in the order rabbit> guinea pig > rat. Ca²+ effect on succinate oxidation rate in state 3 respiration was species- and temperature-dependent and ranged from 0 (rat, 37°C) to +44% (rabbit, 28°C). For mitochondria from all experimental animals, the increase of Ca²+ in physiological range of concentration did not change state 2 respiration rate, and the stimulatory effect of Ca²+ on state 3 respiration was more pronounced at 28°C than at 37°C. The respiratory subsystem was sensitive to Ca²+ ions only in rabbit heart mitochondria. A high positive correlation between Ca²+ ability to stimulate succinate oxidation in state 3 and the control exerted by ATP synthase over the respiratory flux provides argument confirming stimulation of ATP synthase by Ca²+ ions
Affiliation(s): Kauno medicinos universitetas
Kauno medicinos universiteto Biomedicininių tyrimų institutas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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