Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/38673
Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Gražulevičienė, Regina;Nieuwenhuijsen, Mark J;Venclovienė, Jonė;Kostopoulou-Karadanelli, Maria;Krasner, Stuart W;Danilevičiutė, Asta;Balčius, Gediminas;Kapustinskienė Violeta
Title: Individual exposures to drinking water trihalomethanes, low birth weight and small for gestational age risk : a prospective Kaunas cohort study
Is part of: Environmental health [elektroninis išteklius]. London : BioMed Central, Vol. 10, iss. 32 (2011)
Extent: p. 1-11
Date: 2011
Keywords: Drinking water;Trihalomethanes;Low birth weight;Age risk
Abstract: Evidence for an association between exposure during pregnancy to trihalomethanes (THMs) in drinking water and impaired fetal growth is still inconsistent and inconclusive, in particular, for various exposure routes. We examined the relationship of individual exposures to THMs in drinking water on low birth weight (LBW), small for gestational age (SGA), and birth weight (BW) in singleton births. Methods : We conducted a cohort study of 4,161 pregnant women in Kaunas (Lithuania), using individual information on drinking water, ingestion, showering and bathing, and uptake factors of THMs in blood, to estimate an internal dose of THM. We used regression analysis to evaluate the relationship between internal THM dose and birth outcomes, adjusting for family status, education, smoking, alcohol consumption, body mass index, blood pressure, ethnic group, previous preterm, infant gender, and birth year. Results : The estimated internal dose of THMs ranged from 0.0025 to 2.40 mg/d. We found dose-response relationships for the entire pregnancy and trimester-specific THM and chloroform internal dose and risk for LBW and a reduction in BW. The adjusted odds ratio for third tertile vs. first tertile chloroform internal dose of entire pregnancy was 2.17, 95% CI 1.19-3.98 for LBW; the OR per every 0.1 μg/d increase in chloroform internal dose was 1.10, 95% CI 1.01-1.19. Chloroform internal dose was associated with a slightly increased risk of SGA (OR 1.19, 95% CI 0.87-1.63 and OR 1.22, 95% CI 0.89-1.68, respectively, for second and third tertile of third trimester); the risk increased by 4% per every 0.1 μg/d increase in chloroform internal dose (OR 1.04, 95% CI 1.00-1.09). Conclusions : THM internal dose in pregnancy varies substantially across individuals, and depends on both water THM levels and water use habits. Increased internal dose may affect fetal growth
Internet: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100244/
Affiliation(s): Aplinkotyros katedra
Gamtos mokslų fakultetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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