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dc.contributor.authorOsorio-Yanez, Citlalli-
dc.contributor.authorClemente, Diana B. P-
dc.contributor.authorMaitre, Léa-
dc.contributor.authorVives-Usano, Martha-
dc.contributor.authorBustamante, Mariona-
dc.contributor.authorMartinez, David-
dc.contributor.authorCasas, Maribe-
dc.contributor.authorAlexander, Jan-
dc.contributor.authorThomsen, Cathrine-
dc.contributor.authorChatzi, Leda-
dc.contributor.authorGutzkow, Kristine B-
dc.contributor.authorGražulevičienė, Regina-
dc.contributor.authorMartens, Dries S-
dc.contributor.authorPlusquin, Michelle-
dc.contributor.authorSlama, Rémy-
dc.contributor.authorMcEachan, Rosemary R. C-
dc.contributor.authorWright, John-
dc.contributor.authorYang, Tiffany C-
dc.contributor.authorUrquiza, Jose-
dc.contributor.authorTamayo, Ibon-
dc.contributor.authorSunyer, Jordi-
dc.contributor.authorVafeiadi, Marina-
dc.contributor.authorNawrot, Tim S-
dc.contributor.authorVrijheid, Martine-
dc.description.abstractTelomere length and mitochondrial DNA content are considered biomarkers of cellular aging, oxidative stress, and inflammation, but there is almost no information on their association with tobacco smoke exposure in fetal and early life. The aim of this study was to assess whether prenatal and childhood tobacco exposure were associated with leukocyte telomere length (LTL) and mitochondrial DNA (mtDNA) content in children. As part of a multi-centre European birth cohort study HELIX (Human Early-Life Exposome) (n = 1396) we assessed maternal smoking status during pregnancy through questionnaires, and through urinary cotinine levels that were then used to classify women as not exposed to smoking (<10 mu g/L), exposed to secondhand smoke (SHS) (10-50 mu g/L) and active smokers (>50 mu g/L). When the children were around 8 years of age (range: 5.4-12.0 years), childhood SHS tobacco smoke exposure was assessed through an extensive questionnaire and through measurements of urinary cotinine (<3.03 mu g/L non-detected, >3.03 mu g/L detected). Leukocyte mtDNA content and LTL were measured in the children at 8 years employing real time polymerase chain reaction (qPCR). Effect estimates were calculated using multivariate linear regression models for prenatal and childhood exposures adjusted for potential confounders. Maternal cotinine levels indicative of SHS exposure during pregnancy were associated with a decrease of 3.90% in LTL in children (95% CI: -6.68, -0.91), compared with nonsmoking, whereas the association for maternal cotinine levels indicative of active smoking did not reach statistical significance (-3.24%; 95% CI: -6.59, 0.21). Childhood SHS tobacco exposure was not associated with LTL in children. Global SHS exposure during childhood was associated with an increase of 3.51% (95% CI: 0.78, 6.27) in mtDNA content. Our findings suggest that tobacco smoke exposure during pregnancy, even at SHS levels, may accelerate telomere shortening in children and [...]en
dc.description.sponsorshipAplinkotyros katedra-
dc.description.sponsorshipGamtos mokslų fakultetas-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 1-11-
dc.relation.ispartofScience of the total environment. Amsterdam : Elsevier Science BV, 2020, vol. 711-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyEnvironment Complete-
dc.subjectTabako dūmų ekspozocijalt
dc.subjectTobacco exposureen
dc.subjectLeukocyte telomere lengthen
dc.subjectMitochondrial DNA contenten
dc.subject.otherEkologija ir aplinkotyra / Ecology and environmental sciences (N012)-
dc.titleEarly life tobacco exposure and children’s telomere length: The HELIX projecten
dc.typeStraipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)-
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